Regarding https://www.howtoforge.com/community/threads/cant-login-ispconfig-3-2-interface.86395/ Can't reply there. I've found (loglevel debug) that for unknown reason ISPConfig switched to php5.6-fpm. apt remove php5.6-fpm; apachectl restart ; apt install php5.6-fpm did the trick.
Hi! Thank you very much for stepping in. I was so immerse into dealing with clients that I couldn't think straight. In my case it was php8.0-fpm who was stealing the attention. Removing it freed the channel, making all work once again. Again thank you very much.
@FunnyUser thanks for your comment. See https://www.howtoforge.com/community/threads/faq-problem-with-fastcgi-suexec-all-sites-running-under-www-data.86419/ for the actual problem and workaround until the fix is released.