As far as I know, if you do not edit the database tables manually, you have to do that for every user one by one
To do the update in the database that ben mentioned, run the following sql statement in the database: Code: update isp_isp_user SET user_mailscan='1', user_spamfilter='1',antivirus='1',status='u' WHERE status = ''; then edit one of your users in the ISPConfig interface and change e.g. the quota and click on save. ISPConfig will new change the settings for all users.