Hello, I already had this discussion on that page https://www.howtoforge.com/tutorial...l-pureftpd-bind-postfix-doveot-and-ispconfig/ I proposed to move from libapache2-mod-python to libapache2-mod-wsgi-py3 " By: till at: 2020-11-20 17:36:47 Reply @francoisPE: The libs are required to be installed in the way that is described in the guide, so do not alter the commands if you like to get a working setup. The changes you suggested will result in a non-functional system as mod-wsgi is not a direct replacement and also not supported by ISPConfig at all. By: francoisPE at: 2020-12-28 19:30:16 Reply @till, libapache2-mod-python is incompatible with python3... it automatically load python2.7 and make it 'default'. When having libapache2-mod-python, it is impossible to have libapache2-mod-wsgi-py3. Python3 is incompatible with most of the modern web site using python... For me, this is a matter of concern. I don't know if you are able to move ispconfig to libapache2-mod-wsgi-py3. It would be really great! " Today, I see so many websites incompatible with libapache2-mod-python, that I will move to libapache2-mod-wsgi-py3. Dangerous life My understanding is that : mailman (mailman2 in ispc) is incompatible with libapache2-mod-wsgi-py3 Would you please confirm or give me few alerts on what functionality is at risk changing that lib ! Many thanks