I'm wondering if ISPC3 is reloading apache automatically in certain time intervals? The reason I ask is because I have a cron script which makes changes to the .htaccess file, and obviously Apache needs to reload for the changes to take effect. Does it do so automatically, or does apache need to be told to reload?
ISPConfig only does a reload/or restart (unsure) only when a website is created/edited or deleted. Otherwise there is no reason to do so. You'll have to manage this by your own.
apache des not have to be reloaded or restarte when you change a .htaccess file. Changes in .htaccess files take effect immediatle, please see apache documentation for details.