Following the instruction: http://www.howtoforge.com/how-to-set-up-a-postfix-autoresponder-with-autoresponse I setup the autoreponder. It works when i enable it using command line. When I send email the maillog shows: Code: Aug 26 16:20:31 gamma postfix/smtpd[5491]: NOQUEUE: reject: RCPT from gamma.sjgeophysics.com[127.0.0.1]: 550 5.1.1 <[email protected]>: Recipient address rejected: User unknown in virtual mailbox table; from=<[email protected]> to=<[email protected]> proto=ESMTP helo=<192.168.123.42> My mail server use SMTP_AUTH. If I send a normail email, log shows: Code: Aug 26 16:18:33 gamma postfix/smtpd[5249]: connect from gamma.mydomain.com[127.0.0.1] Aug 26 16:18:33 gamma postfix/smtpd[5249]: 252102D70081: client=gamma.mydomain.com[127.0.0.1], sasl_method=LOGIN, [email protected] Aug 26 16:18:33 gamma postfix/cleanup[5273]: 252102D70081: hold: header Received: from 192.168.123.42 (gamma.mydomain.com [127.0.0.1])??by gamma.mydomain.com (Postfix) with ESMTP id 252102D70081??for <[email protected]>; Thu, 26 Aug 2010 16:18:33 -0700 (PD from gamma.mydomain.com[127.0.0.1]; from=<[email protected]> to=<[email protected]> proto=ESMTP helo=<192.168.123.42> Aug 26 16:18:33 gamma postfix/cleanup[5273]: 252102D70081: message-id=<[email protected]> Aug 26 16:18:33 gamma postfix/smtpd[5249]: disconnect from gamma.mydomain.com[127.0.0.1] I can see when try to send email to dynaguy+autoresponse_at_mydomain.com, smtpd somehow try to look up the virtual address table first. It doesn't pass on to the autoresponder script. Please help.