Hi I'm thinking of using URIBL. The only thing that makes me a bit unconftable is the red.uribl.com which contains newly registered domains (age via whois). Meaning that if I register a new domain ISPConfig would reject emails sent from it. Would it work if I entered the new domain to the whitelist or is that list overridden by URIBL?
This depends where you want to add the URIBL. If you add it in postfix directly, the whitelist is ignored because the whitelist is used after the postfix check in spamassassin. If you define the URIBL in spamassassin (/home/admispconfig/ispconfig/tools/spamassassin/....), then it might work.