seeing the following in my maillog after realizing mail wasn't going through: (!)Net::Server: 2020/05/14-21:58:04 Can't connect to TCP port 10024 on ::1 [Cannot assign requested address]\n at line 68 in file /usr/share/perl5/vendor_perl/Net/Server/Proto/TCP.pm status=deferred (connect to 127.0.0.1[127.0.0.1]:10024: Connection refused) I believe this came after ISPConfig 3 update 2 was installed - this server sends minimal email (web services only) to resolve, I tried running the ispconfig_update to install update 3 and let it reconfigure conf files - no love I could see that amavisd.conf include the port assignment for 10024 and clamd was assigned to port 3310 restarting all the mail services (postfix, amavisd, clamd courier-imap, postgrey - down in that order, up in reverse) - no love yum installed all found updates - no love tried lsof -i:10024 to find and kill dead processes - nothing to kill finally this post: https://github.com/kvaps/docker-kolab/issues/27 TLDR; amavis: Can't connect to TCP port 10024 Started seeing this in the logs.. I think it was after I upgraded docker.. I fixed this by adding $inet_socket_bind = '127.0.0.1'; to the end of /etc/amavisd/amavisd.conf in the image. so, not sure how that line got dropped from amavisd.conf - but it wasn't there (maybe lost/not added in Update 2?) added that line, restarted all service as above, and it's working again! my server: "CentOS" 2.6.32-754.29.1.el6.x86_64 #1 SMP Mon Apr 27 15:30:33 UTC 2020 x86_64 x86_64 x86_64 GNU/Linux hope this helps someone else looking for something that works