Ispconfig nginx error: TOO MANY OPEN FILES

Debian10
ISPConfig Version: 3.2.4
nginx/1.14.2
php7.3-fpm
mysql Ver 15.1 Distrib 10.3.29-MariaDB

Hi,

We have an ispconfig cluster with a lot of web, more than 700 for each server, now usually we have an error in the main server, when we add a new web, we get an vhost.err, and when we check nginx logs errors:

open() "/var/log/ispconfig/httpd/xxxxxxxxx/access.log" failed (24: Too many open files)

After read a lot of articles we changed this options:
lsof | wc -l
124438
vi /etc/security/limits.conf (test it before with different values)
root soft nofile unlimited
root hard nofile unlimited
* soft nofile unlimited
* hard nofile unlimited
mysql soft nofile 655350
mysql hard nofile 655350


vi /etc/sysctl.conf:
fs.file-max = 190000

vi /etc/nginx/nginx.conf
worker_rlimit_nofile 250000;
events {
worker_connections 4000;
...
}

But nothings works, Any idea? can you help me please?

Thanks

 

Thanks for your reply Jesse, I did systctl -p to apply those changes and I restarted nginx, php-fpm and mysql as well.

 

Ok I will try to don't restart the server, perfect I will tell you the result, thanks a lot!

 

I restarted the server but still does not work...
Any idea?

Thanks.