In order to get the Pear dir in the include path you need to edit /usr/local/ispconfig/server/conf/vhost.conf.master and add the line in bold to both "# mod_php enabled" sections: Code: # mod_php enabled AddType application/x-httpd-php .php .php3 .php4 .php5 php_admin_value sendmail_path "/usr/sbin/sendmail -t -i -fwebmaster@<tmpl_var name='domain'>" php_admin_value upload_tmp_dir <tmpl_var name='document_root'>/tmp php_admin_value session.save_path <tmpl_var name='document_root'>/tmp #php_admin_value open_basedir <tmpl_var name='document_root'>:/usr/share/php5 [b]php_admin_value include_path ".:/usr/share/pear"[/b] For any existing vhosts you may have edit their conf file in /etc/httpd/conf/sites-enabled and add the same line under the mod_php section.