I have had this problem in the past, when I run php-eaccelerator phpmyadmin stops working. Today I did a fresh build and could not get anything to work including the ISPConfig panel. My solution was to remove php-eaccelerator and replace it with APC by using the following steps: yum install php-pear yum install php-devel yum install httpd-devel pecl install apc echo "extension=apc.so" > /etc/php.d/apc.ini /etc/init.d/httpd start Is this a common error or what am I doing wrong? Should the Perfect Server tutorial be updated? This page has the command in question: http://www.howtoforge.com/perfect-server-centos-6.0-x86_64-ispconfig-3-p5
eAccelerator wasn't being maintained for a while (the projects seems to have been reanimated recently though), therefore I'd recommend APC or XCache.