This is a short HOWTO for anyone that's trying to set up rspamd neighbours for a clustered mail setup. You will need 2 servers with rspamd installed, following these steps: https://www.howtoforge.com/replacing-amavisd-with-rspamd-in-ispconfig/ Take care to add the Apache directives. I added them to the websites that I have for every host, so server1.example.com and server2.example.com had them. Add this to the directives aswell: Code: Header set Access-Control-Allow-Origin https://server1.example.com Take care to change the hostnames. For server1, it should be Code: Header set Access-Control-Allow-Origin https://server2.example.com , for server2 it's vice versa After that, open /etc/rspamd/local.d/options.inc with your favourite text editor and add this to the file: Code: neighbours { server1 { host = "https://server1.example.com:443"; path = "/rspamd/"; } server2 { host = "https://server2.example.com:443"; path = "/rspamd/"; } } Do this on both servers and restart rspamd afterwards: Code: systemctl restart rspamd - Now go to ISPConfig -> System -> Server config -> server1.example.com -> Mail - Copy the rspamd password - Go to server config -> server2.example.com -> Mail - Paste the rspamd password from server1 here After doing this, go to server1.example.com/rspamd, log in, and see if your servers are connected! It should look like this: