There was a thread a short while ago by eKg with instructions on how to enable Postfix for multiple ports to circumvent port 25 filtering at the ISP level. Here are instructions for the flip-side of that coin, Sendmail: After logging into the ISPConfig server as root: cd /etc/mail vi sendmail.mc Find the line : dnl DAEMON_OPTIONS(`Port=submission, Name=MSA, M=Ea')dnl Change it to : DAEMON_OPTIONS(`Port=submission, Name=MSA, M=Ea')dnl If you haven't done so already, Find the line : dnl DAEMON_OPTIONS(`Port=smtp,Addr=127.0.0.1, Name=MTA')dnl Change it to : DAEMON_OPTIONS(`Port=smtp, Name=MTA')dnl to enable non-local access to the SMTP port. Save and exit vi make -C /etc/mail /etc/init.d/sendmail restart If the firewall is enabled, you'll also have to poke a hole in it for submission port 587