Is it possible to have the domains created at: /var/www/vhosts/[domain_name] I've been working with Plesk for quite a few years, so it would be excellent to have it in the same location. Additionally, how does permissions work on these folders? Will people have to login as "Client 1" to directly manipulate their files via SSH, or will they be able to use their Client login? Thanks!
No. ISPConfig uses a different folder structure. There is a folder e.g. under /var/www/clients/client1/web2/ and a symlink under /var/www/domain.com/. What you can do is to create an additional symlink /var/www/vhosts/[domain_name] but do not change the system folder /var/www/clients/client1/web2/ You login with ssh with a ssh user that you created in ispconfig for this website. Every website may have as many ssh users as you allow for this client in the clinet limits.