Here is snipets that work good for me, feel free to comment, in order to make it perfect. Tested with NextCloud 19.0.3. I recommend update Nextcloud with CLI (updater) Please note : the 512MB limit for upload, 2 directives in PHP and 1 in nginx, adjust as you want PHP part : PHP: upload_max_filesize = 512Mpost_max_size = 512Mmax_execution_time = 3600request_terminate_timeout = 3600opcache.enable = 1opcache.enable_cli = 1opcache.interned_strings_buffer = 8opcache.max_accelerated_files = 10000opcache.memory_consumption = 128opcache.save_comments = 1opcache.revalidate_freq = 1memory_limit = 1024Mmbstring.func_overload = 0default_charset = 'UTF-8'output_buffering = 0cgi.fix_pathinfo = 1 NGINX part : PHP: location ~ /\. {##delete## deny all;}location ~ /\.(?!file).* { deny all;}# Add headers to serve security related headers# Before enabling Strict-Transport-Security headers please read into this# topic firstadd_header Strict-Transport-Security "max-age=15768000; includeSubDomains; preload;" always;## WARNING: Only add the preload option once you read about# the consequences in https://hstspreload.org/. This option# will add the domain to a hardcoded list that is shipped# in all major browsers and getting removed from this list# could take several months.add_header Referrer-Policy "no-referrer" always;add_header X-Content-Type-Options "nosniff" always;add_header X-Download-Options "noopen" always;add_header X-Frame-Options "SAMEORIGIN" always;add_header X-Permitted-Cross-Domain-Policies "none" always;add_header X-Robots-Tag "none" always;add_header X-XSS-Protection "1; mode=block" always;# Remove X-Powered-By, which is an information leakfastcgi_hide_header X-Powered-By;location = /robots.txt { allow all; log_not_found off; access_log off;}# The following 2 rules are only needed for the user_webfinger app.# Uncomment it if you're planning to use this app.rewrite ^/.well-known/host-meta /public.php?service=host-meta last;rewrite ^/.well-known/host-meta.json /public.php?service=host-meta-json last;# The following rule is only needed for the Social app.# Uncomment it if you're planning to use this app.rewrite ^/.well-known/webfinger /public.php?service=webfinger last;location = /.well-known/carddav { return 301 $scheme://$host:$server_port/remote.php/dav;}location = /.well-known/caldav { return 301 $scheme://$host:$server_port/remote.php/dav;}location ~ /.well-known/acme-challenge { allow all;}# set max upload sizeclient_max_body_size 512M;fastcgi_buffers 64 4K;# Enable gzip but do not remove ETag headersgzip on;gzip_vary on;gzip_comp_level 4;gzip_min_length 256;gzip_proxied expired no-cache no-store private no_last_modified no_etag auth;gzip_types application/atom+xml application/javascript application/json application/ld+json application/manifest+json application/rss+xml application/vnd.geo+json application/vnd.ms-fontobject application/x-font-ttf application/x-web-app-manifest+json application/xhtml+xml application/xml font/opentype image/bmp image/svg+xml image/x-icon text/cache-manifest text/css text/plain text/vcard text/vnd.rim.location.xloc text/vtt text/x-component text/x-cross-domain-policy;# Uncomment if your server is build with the ngx_pagespeed module# This module is currently not supported.#pagespeed off;location / { rewrite ^ /index.php;}location ~ ^\/(?:build|tests|config|lib|3rdparty|templates|data)\/ { deny all;}location ~ ^\/(?:\.|autotest|occ|issue|indie|db_|console) { deny all;}location ~ ^\/(?:index|remote|public|cron|core\/ajax\/update|status|ocs\/v[12]|updater\/.+|oc[ms]-provider\/.+)\.php(?:$|\/) { fastcgi_split_path_info ^(.+?\.php)(\/.*|)$; set $path_info $fastcgi_path_info; try_files $fastcgi_script_name =404; include fastcgi_params; fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name; fastcgi_param PATH_INFO $path_info; fastcgi_param HTTPS on; # Avoid sending the security headers twice fastcgi_param modHeadersAvailable true; # Enable pretty urls fastcgi_param front_controller_active true;{FASTCGIPASS} fastcgi_intercept_errors on; fastcgi_request_buffering off;}location ~ ^\/(?:updater|oc[ms]-provider)(?:$|\/) { try_files $uri/ =404; index index.php;}# Adding the cache control header for js, css and map files# Make sure it is BELOW the PHP blocklocation ~ \.(?:css|js|woff2?|svg|gif|map)$ { try_files $uri /index.php$request_uri; add_header Cache-Control "public, max-age=15778463"; # Add headers to serve security related headers (It is intended to # have those duplicated to the ones above) # Before enabling Strict-Transport-Security headers please read into # this topic first. #add_header Strict-Transport-Security "max-age=15768000; includeSubDomains; preload;" always; # # WARNING: Only add the preload option once you read about # the consequences in https://hstspreload.org/. This option # will add the domain to a hardcoded list that is shipped # in all major browsers and getting removed from this list # could take several months. add_header Referrer-Policy "no-referrer" always; add_header X-Content-Type-Options "nosniff" always; add_header X-Download-Options "noopen" always; add_header X-Frame-Options "SAMEORIGIN" always; add_header X-Permitted-Cross-Domain-Policies "none" always; add_header X-Robots-Tag "none" always; add_header X-XSS-Protection "1; mode=block" always; # Optional: Don't log access to assets access_log off;}location ~ \.(?:png|html|ttf|ico|jpg|jpeg|bcmap)$ { try_files $uri /index.php$request_uri; # Optional: Don't log access to other assets access_log off;}location ~ \.php$ {##delete## try_files /a1fc5821d2b5d92d0d04aa0046688818.htm @php;}