virtualhost without ispconfig

wich file must to modify to set new virtual host wich is not depending ispconfig?

 

You could manually modify e.g. httd.conf directly or if your apache is configured by that, you have a conf.d directory. Normally every file in there gets included that ends with .conf. (should be applicable for rh/centos/fedora, with debian it is site-enabled or sth. like this)