If I add two or more webmail software like uebimiau and squiremail at the same time on ispconfig, will there be a problem? And if there is, how to remove one of them?
No. That depends on the webmail package. In most cases its enough to delete the dierctorie named like the webmail package in /home/admispconfig/ispconfig/web/ and /home/admispconfig/ispconfig/web/tools/tools/