Solved - thank you for all your help! What I did to upgrade to RoundCube v1.6.4 from v1.3.9 on CentOS 7.9.2009 with Perfect Server and ispconfig v3.2.9p1: #First had to upgrade PHP from .5.6 to 7.4. #But didn't need "epel-release" and "yum-utils" because had already installed on my server: # yum install epel-release # yum install http://rpms.remirepo.net/enterprise/remi-release-7.rpm # yum install yum-utils -y #Change to PHP7.4 default: $ yum-config-manager --enable remi-php74 $ yum update -y #Add "[mysql]" section in "my.conf" config because of old MariaDB: $ vim /etc/my.cnf [mysqld] innodb_large_prefix=1 innodb_file_per_table=1 innodb_file_format=Barracuda #Get roundcube sources and install: $ cd /tmp $ wget https://github.com/roundcube/roundc...oad/1.6.4/roundcubemail-1.6.4-complete.tar.gz $ tar xfz roundcubemail-1.6.4-complete.tar.gz $ cd /tmp/roundcubemail-1.6.4/ $ ./bin/installto.sh /usr/share/roundcubemail/ #Answer both questions with "yes": Upgrading from 1.3.9. Do you want to continue? (y/N)y Running update script at target... WARNING: Replaced config options: (These config options have been replaced or renamed) - 'default_host' was replaced by 'imap_host' Do you want me to fix your local configuration? (y/N) y #Reboot: $ reboot #And finally in my case change SMTP port in roundcube config to "25": $ vim /usr/share/roundcubemail/config/defaults.inc.php $config['smtp_host'] = 'localhost:25';