That is the reason why it is better to have a website for each CMS and not put many CMS in one website. You can set e.g. PHP Safemode only once per website. Yes, if the CMS need different PHP settings. The Host + Domain combination is always unique. But you can create several websites like: cms1.yourdomain.com, cms2.yourdomain.com etc.
Well I understand that. I am in a department of the university. I have one registered hostname and one registered domainname. I respect to this I don't understand your answer. Could you please tell me a bit more.